Highest, especially in authority; holding the highest place in government or power.Highest; highest or most extreme, as to degree, import, etc.; greatest possible; utmost: as, supreme love or wisdom; a supreme hour; supreme baseness.Last.Synonyms and Greatest, first, leading, principal, chief, predominant, paramount, superlative. Supreme is much stronger than any of these.n. The highest point. [Rare.]n. The chief; the superior.n. [capitalized] With the definite article, the Supreme Being. See phrase above.