WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
n. toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
Word Usage
"Freireich finally approached Zubrod with his idea: “I wanted to treat them with full doses of vincristine and amethopterin, combined with the 6-MP and prednisone.”"