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n. A dull red, hard, insensitive lesion that is the first manifestation of syphilis.

n. An ulcer located at the initial point of entry of a pathogen.

n. skin lesion, sometimes associated with certain contagious diseases like syphilis.

n. A venereal sore or ulcer; specifically, the initial lesion of true syphilis, whether forming a distinct ulcer or not; -- called also hard chancre, indurated chancre, and Hunterian chancre.

n. A sore or ulcer arising from the direct application of syphilitic poison.

n. In botany, a disease of the tobacco-plant attributed to Bacillus æruginosus.

n. a small hard painless nodule at the site of entry of a pathogen (as syphilis)

"The disease is already systemic, or constitutional, and the chancre is the local expression of a constitutional disease."

sore   

hard chancre    indurated chancre    hunterian chancre   

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