n. A loss or impairment of the qualities peculiar to the race or kind, or to a type; reduction to a lower type in some scale of being.n. Specifically Loss or impairment of natural or proper qualities; descent to an inferior state; the act of becoming or the state of having become inferior, especially with respect to moral qualities.n. In physiology, any process by which a tissue or substance becomes replaced by some other regarded as less highly organized, less complex in composition, of inferior physiological rank, or less suited for the performance of its original functions.n. A degenerate animal or plant; an organism of a degraded type.n. A progressive departure of a family from the normal condition: shown in the first generation by a nervous temperament, moral depravity, and excesses; in the second by tendency to apoplexy and severe neuroses frequently with alcoholism; in the third by mental derangement, suicide, and intellectual weakness; and in the fourth by hereditary imbecility, deformities, arrested development, and sterility.n. In geology, disintegration produced by weathering.n. Wallerian degeneration proceeding in a direction from the periphery toward the center.