To forsake; desert; abandon; leave to neglect.To deprive, as of property, preferment, or office; divest: used absolutely or with of.To disappoint.Deprived; bereft; under complete lack or privation, whether of what has been lost or of what has never been possessed: with of: as, destitute of honor or of prudence; destitute of the necessaries of life.Without means; indigent; needy; poor: as, the family has been left destitute.A destitute person, or destitute persons collectively.