"It is a heat stable, water soluble, non protein that causes toxicity by inhibition of sodium-potassium pump activity and blockade of neuromuscular transmission. 10 Symptoms of tetrodon poisoning occur within minutes of ingestion and causes headache, diaphoresis, and parasthesias of the lips, tongue, mouth, face fingers and toes rapidly. 8,10 Hypotension and bradycardia may occur in severe cases."