n. Absence or deprivation of advantage; that which prevents success or renders it difficult; any unfavorable circumstance or condition: as, the disadvantage of poverty or imperfect education.n. Loss; injury; prejudice to interest, reputation, credit, profit, or other good: as, to sell goods to disadvantage.n. Synonyms Detriment, injury, hurt, harm, damage, prejudice, drawback.To hinder or embarrass; do something prejudicial or injurious to; put at disadvantage.