n. Alienation of affection, attachment, or good will; estrangement; or, more generally, positive enmity, dislike, or hostility; disloyalty: as, the disaffection of a people to their prince or government; the disaffection of allies; disaffection to religion.n. In a physical sense, disorder; constitutional defect.n. Synonyms Dissatisfaction, ill will, hostility, disloyalty.