n. Lack or absence of ease; uneasiness; pain; distress; trouble; discomfort.n. In pathology: In general, a morbid, painful or otherwise distressing physical condition, acute or chronic, which may result either in death or in a more or loss complete return to health; deviation from the healthy or normal condition of any of the functions or tissues of the body.n. Specifically— An individual case of such a morbid condition; the complex series of pathological conditions causally related to one another exhibited by one person during one period of illness; an attack of sickness.n. A special class of morbid conditions grouped together as exhibiting the same or similar phenomena (symptoms, course, result), as affecting the same organs, or as due to the same causes: as, the diseases of the lungs, as pneumonia, consumption; the diseases of the brain.n. Any disorder or depraved condition or element, moral, mental, social, or political.n. Certain inflammatory conditions of joints attendant on locomotor ataxia.n. See the adjectives.To make uneasy; pain; distress.To affect with disease; make ill; disorder the body or mind of: used chiefly or only in the passive voice or the past participle.