The American Heritage® Dictionary of the English Language, 4th Edition
n. Chronic, often extreme enlargement and hardening of cutaneous and subcutaneous tissue, especially of the legs and external genitals, resulting from lymphatic obstruction and usually caused by infestation of the lymph glands and vessels with a filarial worm.
n. A complication of chronic filariasis, in which nematode worms block the lymphatic vessels, usually in the legs or scrotum, causing extreme enlargement of the infected area.
the GNU version of the Collaborative International Dictionary of English
n. A disease of the skin, in which it become enormously thickened, and is rough, hard, and fissured, like an elephant's hide.
The Century Dictionary and Cyclopedia
n. A name given to several forms of skin-disease.
WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
n. hypertrophy of certain body parts (usually legs and scrotum); the end state of the disease filariasis
Word Usage
"Nowadays, "elephantiasis" is sometimes used for severe lymphedema (a build-up of lymphatic fluid in the leg), sometimes for the specific tropical form of lymphedoma, lymphatic filariasis, caused by a parasitic infestation."