To make familiar or intimate; render conversant by customary use, experience, or intercourse; acquaint closely: as, to familiarize one's self with scenes of distress.To accustom familiarly, as to the sight, knowledge, or practice of something; habituate; inure.. To make familiar in manner; cause to act or be exercised familiarly or affably.To make familiar in regard or experience; make well known; cause to be intimately considered or customary.Also spelled familiarise.