This word is acceptable for play in the US & UK dictionaries that are being used in the following games:

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v. To rouse to impatience or anger; annoy: a loud bossy voice that irritates listeners. See Synonyms at annoy.

v. To chafe or inflame.

v. Physiology To cause physiological activity or response in (an organ or tissue), as by application of a stimulus.

verb-intransitive. To be a cause of impatience or anger.

v. To provoke impatience, anger, or displeasure.

v. To introduce irritability.

v. To cause or induce displeasure or irritation.

v. To induce pain in (all or part of a body or organism).

v. To render null and void.

v. To increase the action or violence of; to heighten excitement in; to intensify; to stimulate.

v. To excite anger or displeasure in; to provoke; to tease; to exasperate; to annoy; to vex.

v. To produce irritation in; to stimulate; to cause to contract. See Irritation, n., 2.

v. To make morbidly excitable, or oversensitive; to fret

adj. Excited; heightened.

To excite to resentment or anger; annoy; vex; exasperate: as, to be irritated by an officious or a tedious person.

To excite to automatic action by external agency, as organic tissue; produce motion, contraction, or inflammation in by stimulation: as, to irritate the skin by chafing or the nerves by teasing.

To give greater force or energy to; excite.

Synonyms Provoke, Incense, etc. (see exasperate); fret, chafe, nettle, sting, annoy, gall, inflame, excite, anger, enrage.

Excited; exasperated; intensified.

To render null and void.

v. excite to some characteristic action or condition, such as motion, contraction, or nervous impulse, by the application of a stimulus

v. excite to an abnormal condition, or chafe or inflame

v. cause annoyance in; disturb, especially by minor irritations

"Tony swung back to him, his expression irritate "What are you talking about?""

please   

irritated    irritates    irritating   

exasperate    peeve    disturb   

irritation    irritatory    irritative   

intensify    stimulate    provoke    tease    exasperate    annoy    vex    fret    excited    heightened   

annoy    unpleasant    Embarrass    disturb    uncomfortable    frustrate    tiresome    ridiculous    depress    excite