This word is acceptable for play in the US & UK dictionaries that are being used in the following games:

• Lexulous
• Wordscraper
• Wordosaur

n. The chief or entire work of a person's lifetime.

n. The main occupation or vocation of a person's life.

n. the principal work of your career

"A lifework is given true substance and value only by the vital individual who puts his life into the struggle."

vocation    career    calling   

lifejacket    dealbreaker    cross-stitching    plant-life    cabinetry    complink    straight-grained    abrasiveness