n. The state of being malignant, in feeling or purpose; extreme malevolence; bitter enmity; malice: as, malignancy of heart.n. In English history, the state of being a malignant; adherence to the royal party in the time of Cromwell and the civil war. See malignant, n., 2.n. The property of expressing malice or evil intent; malignant or threatening nature or character; unpropitiousness.n. In pathology, virulence; tendency to a worse condition: as, the malignancy of a tumor.