n. The act or art of manipulating; manual management; manual and mechanical operation of any kind in science or art, specifically, in pharmacy, the preparation of drugs; in chem., the preparation and employment of utensils, apparatus, and reagents in chemical work.n. Figuratively, the act of operating upon anything by contrivance or influence; management; specifically, insidious management; adjustment or accommodation to one's own purpose or advantage: as, manipulation of voters, figures, or facts.