Hurtful; harmful; baneful; pernicious: as, noxious vapors; noxious animals.Guilty; criminal.Synonyms Noxious, Pernicious, Noisome, pestiferous, pestilent, poisonous, mischievous, corrupting. That which is noxious is actively and energetically harmful. That which is pernicious is as actively destructive. Noisome and noxious were once essentially the same (see Job xxxi. 40, margin; Ps. xci. 3; Ezek. xiv. 21), but noisome now snggests primarily foulness of odor, with a secondary noxiousness to health. Unwholesome vapors that do not offend the sense of smell would now hardly be called noisome.