n. The act of violating sacred things, or of treating them with contempt or irreverence; desecration: as, the profanation of the Lord's day; the profanation of a sanctuary.n. The act of treating with too little reserve or delicacy, or of making common.n. Synonyms Profanation, Desecration, Sacrileye, pollution. The first three words express offenses, amounting almost or quite to outrages, against the religious sentiment, in connection with places, days, etc., taking off their sacred character. They are in the order of strength. Profanation is perhaps most distinctly a matter of irreverence. Sacrilege seems most directly an invasion of the rights of God.