This word is acceptable for play in the US & UK dictionaries that are being used in the following games:

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adj. That operates without a hardware or software buffer

adj. Whose pH is not stabilized with a buffer

"In particular, I was fascinated by the unexplained phenomenon of the transformation of mammalian red blood cells, suspended in unbuffered isotonic saline from discs to perfect spheres when a small drop of the suspension was placed between slide and coverglass."

hydriodic    hypochlorous    dilute    oxy-    deoxyribonucleic    internal-combustion    sulphuric