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n. A change or variation.

n. The quality of being changeable; mutability.

n. One of the sudden or unexpected changes or shifts often encountered in one's life, activities, or surroundings. Often used in the plural. See Synonyms at difficulty.

n. Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.

n. a change, especially in one's life or fortunes.

n. Regular change or succession from one thing to another; alternation; mutual succession; interchange.

n. Irregular change; revolution; mutation.

n. Changing conditions of fortune in one's life; life's ups and downs.

n. Regular change or succession of one thing to another; alternation.

n. A passing from one state or condition to another; irregular change; revolution; mutation: as, the vicissitudes of fortune.

n. mutability in life or nature (especially successive alternation from one condition to another)

n. a variation in circumstances or fortune at different times in your life or in the development of something

"The fact, of course, is that it is just the variety of experience which makes life interesting, -- toil and rest, pain and relief, hope and satisfaction, danger and security, -- and if we once remove the idea of vicissitude from life, it all becomes an indolent and uninspiring affair."

mutableness    mutability    variation    fluctuation   

alternation    interchange    revolution    mutation    change   

indifferentism    vicissitudes    teetotaller    unfamiliarity    chirruping