To lose hope; be without hope; give up all hope or expectation: followed by of before an object.Synonyms Despair, Despond. See despond.To give up hope of; lose confidence in.To cause to despair; deprive of hope.n. Hopelessness; a hopeless state; utter lack of hope or expectation.n. That which causes hopelessness; that of which there is no hope.n. Synonyms Despondency, Despair, Desperation. Despondency is a loss of hope sufficient to produce a loss of courage and a disposition to relax or relinquish effort, the despondent person tending to sink into spiritless inaction. Despair means a total loss of hope; despondency does not. Despair naturally destroys courage and stops all effort, but may produce a new kind of courage and fierce activity founded upon the sense that there is nothing worse to be feared. In this despair is akin to desperation, which is an active state and always tends to produce a furious struggle against adverse circumstances, even when the situation is utterly hopeless.