This word is acceptable for play in the US & UK dictionaries that are being used in the following games:

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n. Cartilage, especially when present in meat.

n. Cartilage; now especially: cartilage present, as a tough substance, in meat.

n. Bone not yet hardened by age and hard work.

n. Cartilage. See cartilage.

n. The popular name of cartilage. See cartilage.

n. Hence Something young and unformed.

n. tough elastic tissue; mostly converted to bone in adults

"A gristle is a substance softer than bone, and harder than the rest, flexible, and serves to maintain the parts of motion."

animal tissue   

in the gristle   

cartilage   

fibrocartilage    arytaenoid    arytenoid    meniscus    hyaline cartilage    thyroid cartilage    semilunar cartilage    arytenoid cartilage    Adam's apple   

gristly    in the gristle    gristled    gristliness   

cartilage   

antimissile    bristle    dismissal    epistle    fissel    fissile    missal    missel    missile    thistle   

sinew    cartilage    blubber    thew    fasciae    tendon    periosteum    fascia    offal    integument