To fatigue or tire out, as with annoying labor, care, importunity, enforced watchfulness, misfortune, etc.; distress by perplexity; wear out, as with toil.Milit.: To annoy by repeated attacks; keep constantly on the defensive.To lay waste or desolate; raid.To rub or scrape.Synonyms Distress, etc. (see afflict); to jade, disturb, exhaust, fag. See trouble.n. Harassment.