Penicillinase

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The American Heritage® Dictionary of the English Language, 4th Edition
  • n. Any of various enzymes that are produced by certain bacteria, including most strains of staphylococci, and that hydrolyze and inactivate penicillin. They are used in medicine to treat allergic reactions to penicillin. Also called beta-lactamase.
    • Wiktionary, Creative Commons Attribution/Share-Alike License
  • n. A specific type of beta-lactamase showing specificity for penicillins.
    • the GNU version of the Collaborative International Dictionary of English
  • n. An enzyme which destroys the antibacterial activity of penicillin by hydrolyzing the amide bond in the beta-lactam ring. Many penicillinases are known, and are produced by a wide variety of bacteria. The production of penicillinase is one of the mechanisms by which bacteria may become resistant to penicillins. Penicillinase production in various bacterial species may be induced, i.e., it may occur only when stimulated by the presence of penicillin in the culture medium, or it may be constitutive, i.e., it may occur whenever the cells are producing protein. Molecular weights of the various penicillinases tend to cluster near 50,000.
    • WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
  • n. enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
    • Hypernym
    Words that are more generic or abstract
    enzyme   
     
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