To set apart; separate.Hence, to discern; have knowledge or understanding (to); know how: usually with an infinitive.To have perception or comprehension; have understanding; discern: followed by of or on.To have personal and practical knowledge (of); be versed or practised; hence, to be expert or dexterous: commonly followed by of.To make difference; signify; matter: used impersonally, and generally with a negative.n. The discriminating or reasoning faculty; the mind.n. Discriminative power; discernment; understanding; reason; wit.n. Reasonableness; propriety; rightness; justice; proper course; wise measure; also, rightful claim; right.n. Reasoning; argument; proof; also, cause; reason.n. Practical knowledge and ability; power of action or execution; readiness and excellence in applying wisdom or science to practical ends; expertness; dexterity.n. A particular power, ability, or art; a gift or attainment; an accomplishment.n. That for which one is specially qualified; one's forte.n. Synonyms Facility, knack. See adroit.